Kazumasa saigoh
Kinki University, Japan
Title: The concentration of oxidized DJ-1 protein (oxDJ-1) in red blood cells is useful for the diagnosis method of Parkinson\\\'s disease
Biography
Biography: Kazumasa saigoh
Abstract
Parkinson disease (PD) are the most common neurodegenerative disorders. Although PD diagnosis is difficulty among Progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and PD. Examination of biomarkers of Parkinson’s disease PD usually focuses on the factors in the cerebrospinal fluid, and there are very few reports on simple biomarkers identified by blood analysis. We determined the level of oxidized DJ-1 protein (oxDJ-1) in red blood cells by the ELISA method. The level of oxDJ-1 was 124.07 ± 13.7 ng oxDJ-1/mg protein in 43 un-treated PD patients group; 88.0 ± 29.8 ng oxDJ-1/mg protein in 9 PSP patients group and 98.8 ± 13.9 ng oxDJ-1/mg protein in 5 MSA patients group. The mean level in 17 control group was 56.0 ± 6.2 ng oxDJ-1/mg protein, showing significant intergroup differences. The clinical courses after intervention with L-dopa treated PD showed a tendency toward decreasing oxDJ-1 levels in the same patient. Our results showed that measurement of oxDJ-1 levels in red blood cells is useful and oxDJ-1 can be used as a biomarker for the early diagnosis of Parkinson’s disease.
