Pathophysiology and pharmacology

The most prominent pathological lesion observed in PD occurs in the basal ganglia of the brain’s extra-pyramidal system. Non-PD patients and without nigrostriatal degeneration develope dyskinesias in response to dopaminergic. It is caused by gradual loss of nerve cells in the brain area called nigra and also by low and falling dopamine levels. The worldwide prevalence of Parkinson disease is anticipated to grow to 2.89 million cases worldwide by 2022.

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