Theme: Leading innovations and remedial insights into the parkinsons disease
Omics Group Conference Series would like to welcome all the Directors, Heads, Deans, Professors, Scientists, Researchers, Doctors and students of neurology department for “International conference on parkinson's disease and movement disorder”on August 11-13, 2015 at Frankfurt, Germany, The theme of Parkinson conference is based on “Leading innovation and remedial insight of parkinsons disease”. This conference is mainly focus will focus the latest and exciting innovations in every area of parkinsons research, and it will offer a unique opportunity for investigators from all over the world to meet, network, and perceive new scientific interactions.
Parkinson’s disease is one of the commonest neurological conditions. It is estimated to affect up to 160 per 100,000 of the general population with an annual incidence of 15–20 per 100,000. Many population studies have shown the rising prevalence with age (up to 2% of the population aged 80 and over). Around 1 in 7 cases are diagnosed below the age of 60 years.The costs of treatment have been estimated at between £560,000 and £1.6 million per 100,000 of the population.
In Germany a 3-year prospective study of the economic cost of PD was performed in 2006. The average annual cost per patient was estimated at €12,091, of which 55,9% accounted for direct costs. Drugs took up the major share of direct costs, €5,763 per year. Indirect costs accounted for €4,851 per patient per year. Within this, 76% of the costs were related to nursing care and the loss of productivity.
Latest Parkinson News revealed: Fetal Cells can cure the Parkinson Disease by injecting into man's brain.
Improving economy and health in countries like USA, Germany, has increased the life span and changed the emphasis from communicable to non-communicable diseases. It is expected that the prevalence of Parkinson’s disease in the 7MM (US, France, Italy, Spain, Germany, Brazil, and Japan) and UK will increase from 3.2m people in 2012 to 4.3m people in 2022. The global treatment for syndromes of the movement disorders market is anticipated to grow from an estimated $ 12,859.8 million in 2014 to $ 21,154.8 million in 2020 at a CAGR of 8.6% during the forecast period. This increase the prevalence of age-related diseases and movement disorders like Parkinson's disease (PD). We review epidemiological studies to describe: a) Developments in interdisciplinary of Parkinson and movement disorders, b) Aggregation and Protein Misfolding and c) potential of epidemiological research in countries with multiple ethnic races and environmental risks for PD, d) methodological issues, e) Prevalence of movement disorders
Track 2: Hyperkinetic Movement Disorders
Parkinson's disease, the most common hyperkinetic movement disorder, which has a much attention from the clinical and scientific community. The Substantial progress has been made in the understanding of the role of the basal ganglia in the pathophysiology of these hyperkinesia disorders and in muscle tone, cognitive processes, motor control and posture. Although therapies that target pathogenesis are still lacking, the management of hyperkinetic movement disorders demands that physicians are knowledgeable about current and novel pharmacological and surgical approaches. In addition to tetra benzene, a monoamine-depleting drug, new formulations of botulin toxin are being increasingly used in the treatment of these movement disorders. Hyperkinetic movement disorders include dystonia, chorea, tics, myoclonus, stereotypies, tremors, restless legs syndrome, Huntington's disease, Tardive Dystonia/ Tardive Dyskinesia, Wilson's disease, and various other disorders with abnormal involuntary movements.
Neurocognitive and Neuromuscular diseases are those that affect the muscles and their direct nervous system control. The session describes that Cognitive and neuropsychiatric issues, Genetic syndromes and autoimmune syndromes in the hinterland of movement disorders. The Role of channelopathies in Movement disorders, clinical spectrum of dystonia’s which are responsive to dopamine-related drugs, Novel biomarkers to differentiate neurodegenerative parkinsonian disorders, neurodegenerative spasticity and Aging, Parkinson related dementia, amnesia and Amyotrophic Lateral Sclerosis (ALS).
Track 4: Risk factors in Parkinson’s disease
A risk factor is something which increases the risk of developing a condition or disease. The risk factors of Parkinson Disease are Age, Gender, Genetics, Toxin exposure, some medications and Area of residence.
Age Where Young adults rarely experience the Parkinson's disease. It begins in middle or late life. The People usually develop the disease around age 60 or older. Heredity occurs when a close relative (mother, father, brother, sister) with Parkinson's disease which may slightly increases the chances of develop the disease. When compared to others. Men are more likely to develop Parkinson's disease than the women. Even Exposure to toxins such as herbicides and pesticides may slightly increase risk of Parkinson's disease.
The Pathophysiology involves the interaction of environmental factors and host susceptibility. A small percentage of cases are genetically linked and genetic factors are being intensely studied. Physiologically, the symptoms associated with Parkinson’s disease are the result of the loss of a number of neurotransmitters, most notably dopamine. Symptoms worsen over time as more and more of the cells affected by the disease are lost. The track Pathophysiology and Neuropharmacology includes Pathophysiology of gastrointestinal dysfunction in Parkinsonism, Management of upper gastrointestinal dysfunction, and dysphagia, Cell death, Bowel dysfunction in Parkinsonism Pathophysiological mechanisms linking Parkinson’s disease and Gaucher’s Disease.
Track 6: Complications of Parkinson’s disease
Parkinson's disease is not fatal, but it can reduce longevity. The disease progresses more quickly in older patients, and may lead to severe incapacity within 10 - 20 years. Older patients also tend to have freezing and greater declines in mental function and daily functioning than younger people. If PD starts without signs of tremor, it is likely to be more severe than if tremor had been present.
Parkinson's disease will seriously impair the standard of life in many people. The physical and emotional impact on the family shouldn't be underestimated because the patient becomes more and more keen about their support. The potential complications are Swallowing issues, Sleep problems and Sleep disorders, Smell dysfunction, Sexual dysfunction, Bradykinesia, Anxiety and Depression, Obsessive compulsive behavior, Hallucinations and mental illness, Drowsiness and incontinence or retention.
Track 7: Managing Parkinson’s disease
Parkinson’s disease (PD) is a chronic disease, it is important to develop and maintain a solid PD management plan. Research has shown that those who take an active role in their care see an improvement in their Parkinson’s symptoms. While many medications treat Parkinson's, none actually reverses the effects of the disease or cures it. To managing Parkinson Disease Nutrition, Optimizing the effect of L-dopa in Parkinson Disease, Exercise, Building a health care team, Complementary therapies, Cognitive and psychiatric disturbances in atypical parkinsonian disorders"
Making an accurate diagnosis of Parkinson’s particularly in its early stages — is difficult. The use of functional neuroimaging in neurodegenerative diseases has increased in recent years, with applications in research in the underlying pathophysiology, aiding in diagnosis, or evaluating new treatments. In Parkinson's disease (PD), these imaging ways have expanded our understanding of the disease on the far side dopaminergic deficits area unit of diagnostics and Neuroimaging for Parkinson disease are Clinical pathological and genetic overlap in parkinsonism, Detecting prodromal Parkinson’s disease, Nuclear imaging to study Laboratory investigations supporting the diagnosis of MSA, PSP and CBD, Utility of next generation sequencing in the diagnosis of parkinsonian disorders, Clinic-genetic correlations in parkinsonian disorders, Therapeutic strategies in genetic forms of proteinopathies, pathophysiology to new treatment strategies Insights from the laboratory and Disease-modifying, animal models and Symptomatic treatments, Update on surgical and medical treatment of the dystonia’s, Instrumental analysis of tremor, Instrumental analysis of parkinsonian symptoms, analysis of gait and postural reflexes, Neuroprotective treatments and Complementary Therapy.
Psychotic symptoms are common in Parkinson’s disease (PD), affecting nearly 50% of all patients over the course of the disease. Neurodegenerative illness in the United States, affecting more than 1 million persons. Disease onset is usually after age 50. In persons older than 70 years, the prevalence is 1.5% to 2.5%.1 while the primary pathology involves degeneration of dopaminergic neurons in the substantia nigra, circuits important in emotion and cognition—such as the serotonergic, adrenergic, cholinergic, frontal dopaminergic pathways, Biological markers, Anxiety disorder, Depression and emotional changes, Lewy Bodies, Antipsychotics, Deep brain Stimulation.
Parkinson’s disease is that the primary growth driver of the worldwide Parkinson’s disease therapeutics. According to the estimates of the World Health Organization, the worldwide prevalence of Parkinson’s disease was valued at over 10 million in 2012. The share of the world’s population above the age of 65 years can increase from 7-membered in 2000 to 16 PF in 2050. The therapeutics of Parkinson Disease includes designing a Clinical trial for parkinsonian disorders, Outcome of clinical trials in PSP, MSA and CBD, therapeutic options for mood, Cognition and Psychosis, Treatment of Parkinson patient with psychosis, Rehabilitation therapies for Parkinson Disease, Medical and Surgical treatment, RNAi and antibody-based therapeutic approaches, therapies targeting autophagy in movement disorders, Isogenic human-induced pluripotent stem cells, Human embryonic stem cell-based therapies in Parkinson disease, Novel proteinopathy based tracers for diagnosis, Therapeutic developments in the treatment of cognitive impairment, Morphological and molecular basis of levodopa-induced dyskinesia’s, Electrophysiological, and their therapeutic implications.
Track 11: Pediatric Movement Disorders:
A movement disorder may be a condition that arises within the brain that causes a baby to move insufficient or too little. Movement disorders will arise from medication, infection, brain injury, autoimmune disease or they'll be inheritable.
This session explains that there is increasing evidence that these disorders are autoimmune and are mediated by antibodies against cell surface or synaptic proteins and cause dysfunction within the central nervous system. Hemiplegia of childhood and rapid onset dystonia-parkinsonism are two separate movement disorders with different dominant mutations in the same gene and Myoclonus shows sudden, brief, shock like movements that may be repetitive or rhythmic.
Non-motor manifestations are integral components of Parkinson disease (PD), and they often have a greater impact on disability and quality of life.
This session will discuss many of the non-motor complications in PD, including Cognitive and neuropsychiatric issues, autonomic, sleep, and sensory difficulties that may occur and the prevalence and tools to assess non-motor features of early and advanced Parkinson’s disease.
- Basic Science and Epidemiology
- Novel Insights and Therapeutics for Parkinsons Disease
- Hyperkinetic Movement Disorders
- Navigating Life with Parkinsons
- Pathophysiology and Neuro pharmacology
- Vasculogenesis and Angiogenesis
- Associate Disorders like Neurocognitive and Degenerative Disorder
- Diagnostic Approaches for Parkinsons Disease
- Pharmacognosy and Advances in Drug Development
- Teleology of Parkinsons Disease
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